We all have moral beliefs. But what if one beleif conflicts with another? DePaul argues that we have to make our beliefs cohere, but that the current coherence methods are seriously flawed. It is not just the arguments that need to be considered in moral enquiry. DePaul asserts that the ability to make sensitive moral judgements is vital to any philosophical inquiry into morality. The inquirer must consider how her life experiences and experiences with literature, film and theatre have influenced (...) her capacity for making moral judgments and attempt to ensure that this capacity is neither naive nor corrupted. (shrink)

Recently, a number of philosophers of biology have endorsed views about random drift that, we will argue, rest on an implicit assumption that the meaning of concepts such as drift can be understood through an examination of the mathematical models in which drift appears. They also seem to implicitly assume that ontological questions about the causality of terms appearing in the models can be gleaned from the models alone. We will question these general assumptions by showing how the same equation (...) — the simple 2 = p2 + 2pq + q2 — can be given radically different interpretations, one of which is a physical, causal process and one of which is not. This shows that mathematical models on their own yield neither interpretations nor ontological conclusions. Instead, we argue that these issues can only be resolved by considering the phenomena that the models were originally designed to represent and the phenomena to which the models are currently applied. When one does take those factors into account, starting with the motivation for Sewall Wright’s and R.A. Fisher’s early drift models and ending with contemporary applications, a very different picture of the concept of drift emerges. On this view, drift is a term for a set of physical processes, namely, indiscriminate sampling processes. (shrink)

What is the Moral Problem? NORMATIVE ETHICS VS. META-ETHICS It is a common fact of everyday life that we appraise each others' behaviour and attitudes from ...

In a recent article, William C. Roach offers a presuppositional critique, which is inspired by Carl F. H. Henry, of Michael R. Licona’s so-called New Historiographical Approach to defending the resurrection. More precisely, Roach attempts to defend six key theses, namely, that the NHA is an evidentialist approach, the NHA is a deductive argument, the NHA is an insufficient approach, believers and unbelievers share no common ground, the NHA does not embrace a correspondence theory of truth, and the presupposition (...) of divine revelation is necessary for apologetics. We respond to each of Roach’s arguments, respectively. (shrink)

This book offers a new interpretation of William James's ethical and religious thought. Michael Slater shows that James's conception of morality, or what it means to lead a moral and flourishing life, is intimately tied to his conception of religious faith, and argues that James's views on these matters are worthy of our consideration. He offers a reassessment of James's 'will to believe' or 'right to believe' doctrine, his moral theory, and his neglected moral arguments for religious faith. And (...) he argues that James's pragmatic account of religion is based on an ethical view of the function of religion and a realist view of the objects of religious belief and experience, and is compatible with his larger conception of pragmatism. The book will appeal to readers interested in the history of modern philosophy, especially pragmatism, as well as those interested in moral philosophy, religion, and the history of ideas. (shrink)

This essay examines one of the most important but understudied aspects of William James’s philosophy, his doctrine of pluralism. It aims to shed new light on the complex and sometimes ambiguous relationship between James’s pluralism and his doctrines of pragmatism and radical empiricism, and shows that his pluralism is a much more pervasive feature of his philosophy than has usually been thought. In particular, the essay shows that James was a pluralist not only in his metaphysical views, but also in (...) his epistemological, ethical, and religious views, and that these latter views are not always clearly dependent upon his pluralistic metaphysics. (shrink)

The clinical Bioresearch Monitoring (BIMO) oversight program of the US Food and Drug Administration (FDA) assesses the quality and integrity of data submitted to the FDA for new product approvals and human subjects protection during clinical studies. A comprehensive program of on-site inspections and data verification, the BIMO program routinely performs random inspections to verify studies submitted to the FDA to support a marketing application. On occasion the FDA will conduct a directed inspection of a specific site or study to (...) look for problems that may have previously been identified. The inspection of a clinical study sometimes uncovers evidence of research fraud or misconduct and it must be decided how to deal with the investigator and the suspect data. The prevention of [or] decreasing the incidence of fraud and misconduct through monitoring by the sponsor is one way to manage compliance issues and can help prevent misconduct. A training program is another way to manage compliance issues in clinical research. While training does not guarantee quality, it does help to ensure that all individuals involved understand the rules and the consequences of research misconduct. (shrink)

This chapter contains sections titled: The Bridgeless Gap? Species Selection The Macroevolution Dispute as a Biological Controversy Postscript: Counterpoint Acknowledgments References.

Science has always engaged with the worldviews of societies and cultures. The theme is of particular importance at the present time as many national and provincial education authorities are requiring that students learn about the nature of science (NOS) as well as learning science content knowledge and process skills. NOS topics are being written into national and provincial curricula. Such NOS matters give rise to at least the following questions about science, science teaching and worldviews: -/- What is a worldview? (...) -/- Does science have a worldview? -/- Are there specific ontological, epistemological and ethical prerequisites for the conduct of science? -/- Does science lack a worldview but nevertheless have implications for worldviews? -/- How can scientific worldviews and practice be reconciled with seemingly discordant religious and cultural worldviews? -/- In which ways do the worldviews of students impact on their interest and learning of science? -/- Should science teachers engage with the worldviews of students? -/- In addition to the NOS curricular impetus for refining understanding of science and worldviews, there are also pressing cultural and social forces that give prominence to questions about science, worldviews and education. There is something of an avalanche of popular literature on the subject that teachers and students are variously engaged by. Additionally the modernisation and science-based industrialisation of huge non-Western populations whose traditional religions and beliefs are different from those that have been associated with orthodox science make very pressing the questions of whether, and how, science is committed to and hence promotes particular worldviews and contradicts others. Hopefully this chapter, and others in the section, will contribute to a more informed understanding of the relationship between science, worldviews and education and provide assistance to teachers who are routinely engaged with the subject. (shrink)

Unlike the most well‐characterized prokaryotic polymerase, E. Coli DNA pol I, none of the eukaryotic polymerases have their own 5′ to 3′ exonuclease domain for nick translation and Okazaki fragment processing. In eukaryotes, FEN‐1 is an endo‐and exonuclease that carries out this function independently of the polymerase molecules. Only seven nucleases have been cloned from multicellular eukaryotic cells. Among these, FEN‐1 is intriguing because it has complex structural preferences; specifically, it cleaves at branched DNA structures. The cloning of FEN‐1 permitted (...) establishment of the first eukaryotic nuclease family, predicting that S. cerevisiae RAD2 (S. pombe Rad13) and its mammalian homolog, XPG, would have similar structural specficity. The FEN‐1 nuclease family includes several similar enzymes encoded by bacteriophages. The crystal structures of two enzymes in the FEN‐1 nuclease family have been solved and they provide a structural basis for the interesting steric requirements of FEN‐1 substrates. Because of their unique structural specificities, FEN‐1 and its family members have important roles in DNA replication, repair and, potentially, recombination. Recently, FEN‐1 was found to specifically associate with PCNA, explaining some aspects of FEN‐1 function during DNA replication and potentially in DNA repair. (shrink)

In the 1960s molecular population geneticists used Monte Carlo experiments to evaluate particular diffusion equation models. In this paper I examine the nature of this comparative evaluation and argue for three claims: first, Monte Carlo experiments are genuine experiments: second, Monte Carlo experiments can provide an important meansfor evaluating the adequacy of highly idealized theoretical models; and, third, the evaluation of the computational adequacy of a diffusion model with Monte Carlo experiments is significantlydifferent from the evaluation of the emperical adequacy (...) of the same diffusion model. (shrink)

Maya in Physics in a synthesis of modern physics and the Advaita Vedanta with an integral thesis emerging out of the confluence. In the exposition of the Advaita Vedanta its philosophy has been reinterpreted in the light of modern science. In this process the vedanta has been demystified and physics dematerialized Instead of being confined to inter school parallelism only this book tries ot present a total vision of the entire cosmos and its dependence on Brahman the transcendental being which (...) is the non dual reality Maya the power of Brahman or the Primordial Unmanifest Nature has been assigned a metaphysical status without violating the traditionality of the Vedanta. Part I of the book deals with classical Newtonian physics, thermodynamics, relativity, quantum physics, particle physics, astrophysics, and cosmology. Part II is a presentation of the Advaita Vedanta, in a modern format. Part III is a confluence of the Advaita Vedanta and modern science (especially physics). An integral thesis emerges out of the confluence. There has been an amalgam of spirituality and science. The whole approach is holistic, synthetic, and integral. (shrink)

In this essay I present two cases for what I term an “unobjectionable” or weak version of metaphysical realism, the first based on a commitment to a version of pragmatism, and the second based on a commitment to theism. I argue that it can be reasonable to accept such a version of realism even if there are no arguments that definitively prove its truth, and that both pragmatists and theists have good reasons to accept it. Although I conceive of these (...) grounds as independent lines of justification, I see no reason in principle why one could not hold both simultaneously. This is not to suggest that there are not versions of pragmatism or theism that are incompatible with each other, but rather only that pragmatism and theism as such are not mutually exclusive views. (shrink)

I’m not sure one even needs to think a state of affairs is true for us to take attitudinal pleasure in it. We surely take pleasure in imagining states of affairs. In such a case, we are well aware that the state of affairs that is the object of our enjoyment does not obtain. What is the proper account of the pleasure we take from imagining? I am fairly sure this is not a type of sensory pleasure. Would it make (...) sense to say that what S is attitudinally pleased by is the state of affairs consisting of S’s imagining p rather than p? I don’t think this will do. It seems possible for S to take pleasure in the imagined state of affairs, p, but not in the state of affairs of S’s imagining p. Consider the case of Chastity, who has had a puritanical upbringing. One day Chastity imagines a torrid romantic encounter with one of her co-workers. Quite in spite of herself, Chastity is pleased by the state of affairs which she merely imagines. But her upbringing has left its mark on her, so she feels very guilty about allowing her thoughts to run in such an unwholesome direction. Chastity is pained by the state of affairs consisting in her imagining the encounter. (shrink)

Discussing Keith Donnellan's distinction between attributive and referential uses of descriptions, Gareth Evans considered a speaker he found it natural to describe as having “given expression to” a singular thought, though he insisted she was not referring to the person she has in mind. On accounts otherwise similar to Evans's, to express a singular thought just is to refer. Thus, as he does not explain why this speaker might speak this way, it is tempting to ignore this as a slip. (...) On the contrary, I shall argue, Evans has good reason to deny that picture of reference. My interest, though, is in the case itself. It turns out it is a presentational use of descriptions: it provides its audience a cognitive ability they would otherwise lack. This characterization raises deep theoretical questions which I only begin to address here. My goal is to show that we ought to address those questions, for there is no better way of understanding examples like Evans's than to see them as presentational. (shrink)

During the 1960s and 1970s population geneticists pushed beyond models of single genes to grapple with the effect on evolution of multiple genes associated by linkage. The resulting models of multiple interacting loci suggested that blocks of genes, maybe even entire chromosomes or the genome itself, should be treated as a unit. In this context, Richard Lewontin wrote his famous 1974 book The Genetic Basis of Evolutionary Change, which concludes with an argument for considering the entire genome as the unit (...) of selection as a result of linkage. Why did Lewontin and others devote so much intellectual energy to the “complications of linkage” in the 1960s and 1970s? We argue that this attention to linkage should be understood in the context of research on chromosomal inversions and co-adapted gene complexes that occupied mid-century evolutionary genetics. For Lewontin, the complications of linkage were an extension of this chromosomal focus expressed in the new language of models for linkage disequilibrium. (shrink)